Recent Publications

Structure of the human cGAS–DNA complex reveals enhanced control of immune surveillance.
Zhou W*, Whiteley AT*, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ.
Cell. 2018; 174, 300–311. (Link)

Ancient origin of cGAS-STING reveals mechanism of universal 2′,3′ cGAMP signaling.

Kranzusch PJ*, Wilson SC*, Lee ASY, Berger JM, Doudna JA, Vance RE.
Molecular Cell. 2015; 59(6), 891–903. (Link)

Structure-guided reprogramming of human cGAS dinucleotide linkage specificity.
Kranzusch PJ, Lee ASY, Wilson SC, Solovykh MS, Vance RE, Berger JM, Doudna JA.
Cell. 2014; 158(5), 1011–1021. (Link)

Contact

Philip J. Kranzusch, Ph.D.
Assistant Professor of Microbiology and Immunobiology
Harvard Medical School
Dana-Farber Cancer Institute
philip_kranzusch [at] dfci.harvard.edu

© 2018, Kranzusch Lab