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2017

cGAS Conducts Micronuclei DNA Surveillance.
de Oliveira Mann CC, Kranzusch PJ.
Trends in Cell Biology. 2017; 27(10): 697698. PMID: 28882413

Dynamic control of X-chromosome conformation and repression by a histone H4K20 demethylase.
Brejc K, Bian Q, Uzawa S, Wheeler BS, Anderson EC, King DS, Kranzusch PJ, Preston CG, Meyer BJ.
Cell. 2017; 171(1): 85-102. PMID 28867287

A broad-spectrum inhibitor of CRISPR-Cas9.
Harrington LB, Doxzen KW, Ma E, Liu J, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA.
Cell. 2017; 170(6): 1224-1233. PMID 28844692

2016

eIF3d is an mRNA cap-binding protein required for specialized translation initiation.
Lee AS, Kranzusch PJ, Doudna JA, Cate JD.
Nature. 2016; 536(7614): 96-9. PMID: 27462815

A bacterial Argonaute with noncanonical guide RNA specificity.
Kaya E, Doxzen KW, Knoll KR, Wilson RC, Strutt SC, Kranzusch PJ, Doudna JA.
PNAS. 2016; 113(15):4057-62. PMID: 27035975

2015

Foreign DNA capture during CRISPR-Cas adaptive immunity.
Nuñez JK, Harrington LB, Kranzusch PJ, Engelman AN, Doudna JA.
Nature. 2015; 527(7579):535-8. PMID: 26503043

Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Kranzusch PJ, Wilson SC, Lee AS, Berger JM, Doudna JA, Vance RE.
Molecular Cell. 2015; 59(6):891-903. PMID: 26300263

eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.
Lee AS, Kranzusch PJ, Cate JH.
Nature. 2015; 522(7554):111-4. PMID: 25849773

2014

Structure-guided reprogramming of human cGAS dinucleotide linkage specificity.
Kranzusch PJ, Lee AS, Wilson SC, Solovykh MS, Vance RE, Berger JM, Doudna JA.
Cell. 2014; 158(5):1011-21. PMID: 25131990

Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity.
Nuñez JK, Kranzusch PJ, Noeske J, Wright AV, Davies CW, Doudna JA.
Nature Structural & Molecular Biology. 2014; 21(6):528-34. PMID: 24793649

African origin of the malaria parasite Plasmodium vivax.
Liu W, Li Y, Shaw KS, Learn GH, Plenderleith LJ, Malenke JA, Sundararaman SA, Ramirez MA, Crystal PA, Smith AG, Bibollet-Ruche F, Ayouba A, Locatelli S, Esteban A, Mouacha F, Guichet E, Butel C, Ahuka-Mundeke S, Inogwabini BI, Ndjango JB, Speede S, Sanz CM, Morgan DB, Gonder MK, Kranzusch PJ, Walsh PD, Georgiev AV, Muller MN, Piel AK, Stewart FA, Wilson ML, Pusey AE, Cui L, Wang Z, Färnert A, Sutherland CJ, Nolder D, Hart JA, Hart TB, Bertolani P, Gillis A, LeBreton M, Tafon B, Kiyang J, Djoko CF, Schneider BS, Wolfe ND, Mpoudi-Ngole E, Delaporte E, Carter R, Culleton RL, Shaw GM, Rayner JC, Peeters M, Hahn BH, Sharp PM.
Nature Communications. 2014; 5:3346. PMID: 24557500

2013

cGAS dimerization entangles DNA recognition.
Kranzusch PJ, Vance RE.
Immunity. 2013; 39(6):992-4. PMID: 24332024

Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity.
Kranzusch PJ, Lee AS, Berger JM, Doudna JA.
Cell Reports. 2013; 3(5):1362-8. PMID: 23707061

The polymerase of negative-stranded RNA viruses.
Morin B, Kranzusch PJ, Rahmeh AA, Whelan SP.
Current Opinion in Virology. 2013; 3(2):103-10. PMID: 23602472

2012

Architecture and regulation of negative-strand viral enzymatic machinery.
Kranzusch PJ, Whelan SP.
RNA Biology. 2012; 9(7):941-8. PMID: 22767259

2011

Arenavirus Z protein controls viral RNA synthesis by locking a polymerase-promoter complex.
Kranzusch PJ, Whelan SP.
PNAS. 2011; 108(49):19743-8. PMID: 22106304

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1.
Carette JE, Raaben M, Wong AC, Herbert AS, Obernosterer G, Mulherkar N, Kuehne AI, Kranzusch PJ, Griffin AM, Ruthel G, Dal Cin P, Dye JM, Whelan SP, Chandran K, Brummelkamp TR.
Nature. 2011; 477(7364):340-3. PMID: 21866103

Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry.
Radoshitzky SR, Warfield KL, Chi X, Dong L, Kota K, Bradfute SB, Gearhart JD, Retterer C, Kranzusch PJ, Misasi JN, Hogenbirk MA, Wahl-Jensen V, Volchkov VE, Cunningham JM, Jahrling PB, Aman MJ, Bavari S, Farzan M, Kuhn JH.
Journal of Virology. 2011; 85(17):8502-13. PMID: 21697477

2010

Molecular architecture of the vesicular stomatitis virus RNA polymerase.
Rahmeh AA, Schenk AD, Danek EI, Kranzusch PJ, Liang B, Walz T, Whelan SP.
PNAS. 2010; 107(46):20075-80. PMID: 21041632

Assembly of a functional Machupo virus polymerase complex.
Kranzusch PJ, Schenk AD, Rahmeh AA, Radoshitzky SR, Bavari S, Walz T, Whelan SP.
PNAS. 2010; 107(46):20069-74. PMID: 20978208

Origin of the human malaria parasite Plasmodium falciparum in gorillas.
Liu W, Li Y, Learn GH, Rudicell RS, Robertson JD, Keele BF, Ndjango JB, Sanz CM, Morgan DB, Locatelli S, Gonder MK, Kranzusch PJ, Walsh PD, Delaporte E, Mpoudi-Ngole E, Georgiev AV, Muller MN, Shaw GM, Peeters M, Sharp PM, Rayner JC, Hahn BH.
Nature. 2010; 467(7314):420-5. PMID: 20864995

Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin.
Radoshitzky SR, Dong L, Chi X, Clester JC, Retterer C, Spurgers K, Kuhn JH, Sandwick S, Ruthel G, Kota K, Boltz D, Warren T, Kranzusch PJ, Whelan SP, Bavari S.
Journal of Virology. 2010; 84(20):10569-80. PMID: 20686043

Molecular epidemiology of simian immunodeficiency virus infection in wild-living gorillas.
Neel C, Etienne L, Li Y, Takehisa J, Rudicell RS, Bass IN, Moudindo J, Mebenga A, Esteban A, Van Heuverswyn F, Liegeois F, Kranzusch PJ, Walsh PD, Sanz CM, Morgan DB, Ndjango JB, Plantier JC, Locatelli S, Gonder MK, Leendertz FH, Boesch C, Todd A, Delaporte E, Mpoudi-Ngole E, Hahn BH, Peeters M.
Journal of Virology. 2010; 84(3):1464-76. PMID: 19906908

2009

Ribose 2'-O methylation of the vesicular stomatitis virus mRNA cap precedes and facilitates subsequent guanine-N-7 methylation by the large polymerase protein.
Rahmeh AA, Li J, Kranzusch PJ, Whelan SP.
Journal of Virology. 2009; 83(21):11043-50. PMID: 19710136

© 2017, Kranzusch Lab