Recent Publications

cGAS-like receptors sense RNA and control 3′2′-cGAMP signaling in Drosophila.
Slavik KM, Morehouse BR, Ragucci AE, Zhou W, Ai X, Chen Y, Li L, Wei Z, Bähre H, König M, Seifert R, Lee ASY, Cai H, Imler JL, Kranzusch PJ.
Nature. 2021; 597(7874), 109–113. (Link).

Molecular basis of CD-NTase nucleotide selection in anti-phage defense.
Govande AA, Duncan-Lowey B, Eaglesham JB, Whiteley AT, Kranzusch PJ.
Cell Reports. 2021; 35, 109206. (Link).

cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing.
Zhou W, Mohr L, Maciejowski J, Kranzusch PJ.
Molecular Cell. 2021; 81(4), 739–755. (Link).

STING cyclic dinucleotide sensing originated in bacteria.
Morehouse BR, Govande AA, Millman A, Keszei AFA, Lowey B, Ofir G, Shao S, Sorek R, Kranzusch PJ. Nature. 2020; 586(7829), 429–433. (Link).

Contact

Philip J. Kranzusch, Ph.D.
Associate Professor of Microbiology
Harvard Medical School
Dana-Farber Cancer Institute
philip_kranzusch [at] dfci.harvard.edu

© 2021, Kranzusch Lab