Recent Publications

A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense.
Chang RB, Toyoda HC, Hobbs SJ, Richmond-Buccola D, Wein T, Burger N, Chouchani ET, Sorek R, Kranzusch PJ.
Molecular Cell. 2025; 85(16), 3151–3165. (Link).

A DNA-gated molecular guard controls bacterial Hailong anti-phage defence.
Tan JMJ, Melamed S, Cofsky JC, Syangtan D, Hobbs SJ, Marmol JD, Jost M, Kruse AC, Sorek R, Kranzusch PJ.
Nature. 2025; 643(8072), 794–800. (Link).

Animal and bacterial viruses share conserved mechanisms of immune evasion.
Hobbs SJ, Nomburg J, Doudna JA, Kranzusch PJ.
Cell. 2024; 187(20), 5530–5539. (Link). 

Structural basis of Gabija anti-phage defence and viral immune evasion.
Antine SP, Johnson AG, Mooney SE, Leavitt A, Mayer ML, Yirmiya E, Amitai G, Sorek R, Kranzusch PJ.
Nature. 2024; 625(7994), 360–365. (Link).