Recent Publications

A large-scale type I CBASS antiphage screen identifies the phage prohead protease as a key determinant of immune activation and evasion.
Richmond-Buccola D, Hobbs SJ, Garcia JM, Toyoda H, Gao J, Shao S, Lee ASY, Kranzusch PJ.
Cell Host & Microbe. 2024; 32(7), 1074–1088. (Link).

Structural basis of Gabija anti-phage defence and viral immune evasion
.
Antine SP, Johnson AG, Mooney SE, Leavitt A, Mayer ML, Yirmiya E, Amitai G, Sorek R, Kranzusch PJ.
Nature. 2024; 625(7994), 360–365. (Link). 

cGLRs are a diverse family of pattern recognition receptors in animal innate immunity
.
Li Y, Slavik KM, Toyoda HC, Morehouse BR, de Oliveira Mann CC, Elek A, Levy S, Wang Z, Mears KS, Liu J, Kashin D, Guo X, Mass T, Sebé-Pedrós A, Schwede F, Kranzusch PJ.
Cell. 2023; 186(15), 3261–3276. (Link).

Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity.
Hobbs SJ, Wein T, Lu A, Morehouse BR, Schnabel J, Leavitt A, Yirmiya E, Sorek R, Kranzusch PJ.
Nature. 2022; 605(7910), 522–526. (Link).

Contact

Philip J. Kranzusch, Ph.D.
Professor of Microbiology 
Harvard Medical School
Dana-Farber Cancer Institute
philip_kranzusch [at] dfci.harvard.edu


© 2024, Kranzusch Lab