Immunology Structure and Evolution

Human cGAS and animal cGLRs (cGAS-like receptors)

cGAS–DNA PDB: 6CT96CTA

Apo cGAS PDB: 4KM5

Human MB21D2 (C3orf59) PDB: 7LT1

T. castaneum cGLR PDB: 7LT2

S. pistillata cGLR1 PDB: 8GJY

C. virginica cGLR1 PDB: 8GJW

STING signaling

Human STING PDB: 8GJX

Bacterial STING PDB: 6WT46WT5

Bacterial TIR-STING Filament PDB: 7UN87UN97UNA

Drosophila STING PDB: 7MWY7MWZ

Oyster TIR-STING PDB: 6WT66WT7

Zebrafish STING–TRAF6 PDB: 6MYD

Anemone STING PDB: 5CFL5CFM, 5CFN5CFO5CFP, 5CFQ5CFR

S. pistillata STING PDB: 8EFM8EFN, 8GJZ

Animal innate immunity

RECON–cAAG PDB: 6M7K

hTREX1–DNA PDB: 7TQN7TQO7TQP7TQQ

mTREX1 E198K PDB: 6W10

mDecr-1–2′–5′ OA PDB: 7UCW

Viral immune evasion proteins

VACV Poxin PDB: 6EA66EA86EA9

Baculovirus Poxin PDB: 6XB36XB4

Insect Poxin PDB: 6XB56XB6

Poxvirus A47L PDB: 8GBE

Bacteria anti-phage defense nucleotide signaling enzymes

CBASS CD-NTase enzymes 
PDB: 4TXY4TXZ4TY06E0K6E0L,
6E0M6E0N6E0O6WT86WT97LJL,
7LJM7LJN7LJO

Pycsar PycC PDB: 7R65

CBASS/Pycsar AGS-C domain PDB: 9ARD

Bacteria anti-phage defense nucleotide signaling receptors

CBASS Cap4 PDB: 6VM56VM66WAM6WAN

CBASS Cap15 PDB: 7N347N35

Bacterial anti-phage defense systems

Gabija PDB: 8SM3

Bacterial gasdermin PDB: 7N507N517N528SL0 (PDBDev)

RADAR PDB: 8FNT8FNU8FNV8FNW

Phage immune evasion proteins

Anti-CBASS Acb1 PDB: 7T267T27

Anti-Pycsar Apyc1 PDB: 7T287U2R7U2S

Anti-Thoeris Tad1 PDB: 7UAV7UAW8SMD

Anti-Thoeris Tad2 PDB: 8SME8SMF8SMG

Anti-Gabija Gad1 PDB: 8U7I (PDBDev)

Anti-Hachiman Had1 PDB: 8TTO

Research Collaborations

With Amy Lee, Jaime Cate 
Lee Lab – Harvard Medical School

Protein Translation
eIF3d Cap-Recognition Domain

PDB: 5K4B5K4C5K4D

With James Nuñez
Doudna Lab – UC-Berkeley

CRISPR Bacterial Immunity
E. coli Cas1–Cas2 Complex

PDB: 4P6I

With James Nuñez, Lucas Harrington
Doudna Lab – UC-Berkeley

CRISPR Bacterial Immunity
E. coli Cas1–Cas2–dsDNA Complex

PDB: 5DS45DS55DS6

With Kevin Doxzen, Emine Kaya
Doudna Lab – UC-Berkeley

Atypical Argonaute Complex
M. piezophila Argonaute–ssRNA

PDB: 5I4A

With Lucas Harrington, Kevin Doxzen 
Doudna Lab – UC-Berkeley

CRISPR Bacterial Immunity  
NmeCas9–AcrIIC1 Inhibitory Complex

PDB: 5VGB

With Katjuša Brejc 
Meyer Lab – UC-Berkeley

Chromatin H4K20 Modification
C. elegans DPY-21 Demethylase

PDB: 5UQD

With Zach Hallberg, Kevin Doxzen
Hammond Lab – University of Utah

Geobacter Hypr GGDEF
cGAMP Synthase

PDB: 6D9M

w/ Anna Seminara, Daniel Dumitrescu 
Hatzios Lab – Yale University

Helicobacter EgtU
ergothioneine receptor

PDB: 8DP68DP7

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