Immunology Structure and Evolution

Human cGAS Signaling

cGAS–DNA PDB: 6CT9, 6CTA

Apo cGAS PDB: 4KM5

STING Signaling

Bacterial STING PDB: 6WT4, 6WT5

Drosophila STING PDB: 7MWY, 7MWZ

Oyster TIR-STING PDB: 6WT6, 6WT7

Zebrafish STING–TRAF6 PDB: 6MYD

Anemone STING PDB: 5CFL, 5CFM, 5CFN, 5CFO, 5CFP, 5CFQ, 5CFR

cGAS-like Receptors (cGLRs)

Human MB21D2 (C3orf59) PDB: 7LT1

T. castaneum cGLR PDB: 7LT2

Poxvirus 2′3′-cGAMP Nuclease

VACV Poxin PDB: 6EA6, 6EA8, 6EA9

Baculovirus Poxin PDB: 6XB3, 6XB4

Insect Poxin PDB: 6XB5, 6XB6

Animal Innate Immunity

RECON–cAAG PDB: 6M7K

TREX1 E198K PDB: 6W10

Bacterial CBASS CD-NTases
(cGAS/DncV-like NTases)

PDB: 4TXY, 4TXZ, 4TY0, 6E0K, 6E0L,
6E0M, 6E0N, 6E0O, 6WT8, 6WT9, 7LJL,
7LJM, 7LJN, 7LJO

Bacterial Anti-Phage Defense

CBASS Cap4 PDB: 6VM5, 6VM6, 6WAM, 6WAN

Pycsar PycC PDB: 7R65

Research Collaborations

With Amy Lee, Jaime Cate
Lee Lab – Brandeis University

Protein Translation
eIF3d Cap-Recognition Domain

PDB: 5K4B, 5K4C, 5K4D

With James Nuñez
Doudna Lab – UC-Berkeley

CRISPR Bacterial Immunity
E. coli Cas1–Cas2 Complex

PDB: 4P6I

With James Nuñez, Lucas Harrington
Doudna Lab – UC-Berkeley

CRISPR Bacterial Immunity
E. coli Cas1–Cas2–dsDNA Complex

PDB: 5DS4, 5DS5, 5DS6

With Kevin Doxzen, Emine Kaya
Doudna Lab – UC-Berkeley

Atypical Argonaute Complex
M. piezophila Argonaute–ssRNA

PDB: 5I4A

With Lucas Harrington, Kevin Doxzen
Doudna Lab – UC-Berkeley

CRISPR Bacterial Immunity
NmeCas9–AcrIIC1 Inhibitory Complex

PDB: 5VGB

With Katjuša Brejc
Meyer Lab – UC-Berkeley

Chromatin H4K20 Modification
C. elegans DPY-21 Demethylase

PDB: 5UQD

With Zach Hallberg, Kevin Doxzen
Hammond Lab – University of Utah

Geobacter Hypr GGDEF
cGAMP Synthase

PDB: 6D9M

© 2021, Kranzusch Lab