2021 - 10 - 18 Max Fels starts in the lab as a postdoctoral fellow joint with the Lee Lab.

2021 - 10 - 12 Our paper in collaboration with the Sorek Lab on the discovery of Pycsar anti-phage defense is published in Cell.

• Congratulations to co-first authors Ben and Nitzan, all of the co-authors from our labs, and our collaborators in the Shao Lab.

• Manuscript: "Cyclic CMP and cyclic UMP mediate bacterial immunity against phages"

• View our new structure of the Pycsar PycC cUMP cyclase: PDB 7R65

2021 - 10 - 05 Our research on cGAS-like receptors is supported by the NIH Director's New Innovator program.

2021 - 09 - 14 Brianna successfully defends her thesis research, congratulations Dr. Duncan-Lowey!

2021 - 09 - 03 Wanyu Li from HMS Virology starts a graduate rotation in the lab.

2021 - 08 - 30 Desmond Richmond-Buccola joins the lab for his graduate dissertation research.

2021 - 08 - 19 Apurva successfully defends her thesis research, congratulations Dr. Govande!

2021 - 08 - 09 Allen Lu starts in the lab as a research technician.

2021 - 08 - 04 Sam wins a postdoctoral fellowship from the Cancer Research Institute.

2021 - 07 - 25 Alex wins a postdoctoral fellowship from the Life Sciences Research Institute.

2021 - 07 - 14 Our paper on the discovery of animal cGAS-like receptors (cGLRs) is published in Nature.

• Congratulations to Kailey, all of the co-authors from our lab, and our collaborators in the Imler, Cai, Lee, and Seifert Labs.

• Manuscript: "cGAS-like receptors sense RNA and control 3′2′-cGAMP signaling in Drosophila"

• View our new structures of animal cGLRs and the Drosophila STING–3′2′-cGAMP complex: PDB 7LT1, 7LT2, 7MWY, 7MWZ

• Read highlights of our work:

• "cGAS-like receptors put a sting into the evolution of immune defence" (Cara West and Neal Silverman, in Nature)

• "cGAS-like receptors: ancient catches of viral nucleic acids" (Taoyong Chen and Xuetao Cao, in Trends in Immunology)

2021 - 06 - 01 Our paper on CD-NTase synthesis of antiviral nucleotide second messengers is published in Cell Reports.

• Congratulations to Apurva and all of the co-authors from our lab.

• Manuscript: "Molecular basis of CD-NTase nucleotide selection in CBASS anti-phage defense"

• View our new structures of a cyclic dinucleotide and cyclic trinucleotide synthesizing CD-NTases: PDB 7LJL, 7LJM, 7LJN, 7LJO

2021 - 05 - 04 Brianna Lowey is selected as the Haverford College Young Alumni of the Year. Congratulations Brianna!

2021 - 05 - 03 Julia Schnabel from HMS Virology starts a graduate rotation in the lab.

2021 - 03 - 11 Wen accepts a faculty position at Southern University of Science and Technology (SUSTech) in China, congratulations Wen!

2021 - 02 - 23 Yao Li starts in the lab as a postdoctoral fellow.

2021 - 02 - 18 Our paper on cGAS-DNA condensate formation resisting TREX1 regulation is publised in Molecular Cell.

• Congratulations to Wen and our collaborators in the Maciejowski Lab.

• Manuscript: "cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing"

• View our new structure of a TREX1 variant associated with autoimmunity: PDB 6W10

• Read Andrea Ablasser's preview of our work: "The spatial organization of cGAS-TREX1 interactions"

2020 - 12 - 01 Kacie McCarty leaves the lab to start graduate school at NYU, good luck Kacie!

2020 - 12 - 01 Our work on nucleotide second messenger signaling is supported by The Mathers Foundation.

2020 - 11 - 16 Our paper on poxin 2′3′-cGAMP nucleases in diverse insect viruses and insect hosts is published in eLife.

• Congratulations to James and Kacie.

• Manuscript: "Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host-pathogen conflict"

• View our new structures of viral and host poxins: PDB 6XB3, 6XB4, 6XB5, 6XB6

2020 - 11 - 03 Sam Hobbs starts in the lab as a postdoctoral fellow.

2020 - 10 - 05 Wen is a recipient of the 2020 Charles A. King Trust Award.

2020 - 09 - 09 Desmond Richmond-Buccola from HMS Virology starts a graduate rotation in the lab.

2020 - 09 - 02 Our paper on the origin of STING cyclic dinucleotide sensing in bacteria is published in Nature.

• Congratulations to Ben, co-authors, and our collaborators in the Sorek Lab and Shao Lab.

• Manuscript: "STING cyclic dinucleotide sensing originated in bacteria"

• View our new structures of bacterial STING receptors and cGAS-like enzymes in CBASS and metazoan immunity: PDB 6WT4, 6WT5, 6WT6, 6WT7, 6WT8, 6WT9

• Read Justin Jenson's and James Chen's preview of our work: "Bacteria sting viral invaders"

2020 - 08 - 28 Our work on CD-NTase enzymes is supported by the Burroughs Wellcomme Fund PATH program.

2020 - 07 - 07 Ady Ragucci starts in the lab as a research technician.

2020 - 07 - 07 Alex Johnson starts in the lab as a postdoctoral fellow.

2020 - 06 - 16 Nora McNamara-Bordewick starts in the lab as a research technician.

2020 - 06 - 15 Our paper on CARF receptors and 2′–5′-linkages in CBASS / CD-NTase antiviral immunity is published in Cell.

• Congratulations to Brianna, co-authors, and our collaborators in the Lee Lab, Shao Lab, Mekalanos Lab, Jain Lab, and at Biolog.

• Manuscript: "CBASS immunity uses CARF-related effectors to sense 3′–5′- and 2′–5′-linked cyclic oligonucleotide signals and protect bacteria from phage infection"

• View our new structures of Cap4 receptors in CBASS immunity: PDB 6VM5, 6VM6, 6WAM, 6WAN

• Read Malcolm White's preview of our work: "Bacteria SAVED from Viruses"

2020 - 04 - 16 James successfully defends his thesis research, congratulations Dr. Eaglesham!

2020 - 03 - 02 James is a recipient of the 2020 Harold W. Weintraub Graduate Student Award.

2020 - 01 - 06 Our work on cGAS-STING regulation is supported by The Mark Foundation for Cancer Research.

2019 - 09 - 16 Lauren Davancaze from HMS BBS starts a graduate rotation in the lab.

2019 - 09 - 09 Our work is recognized with the American Society for Microbiology Award for Early Career Basic Research.

2019 - 06 - 18 Kailey Slavik joins the lab for her graduate dissertation work.

2019 - 06 - 15 Aaron accepts a faculty position at CU Boulder, congratulations to the Whiteley Lab opening soon!

2019 - 06 - 14 Our work on cGAS and CD-NTase enzymes is supported by the Pew Biomedical Scholars program.

2019 - 05 - 10 Wen wins a postdoctoral fellowship from the Benacerraf foundation.

2019 - 05 - 01 Ben wins an NIH postdoctoral fellowship from the NRSA F32 program.

2019 - 04 - 23 Our paper with the Lee Lab on STING signaling specificity is published today in Cell Reports.

• Congratulations to Carina, co-authors, and our collaborators in the Kagan Lab.

• Read the manuscript: "Modular architecture of the STING C-terminal tail allows interferon and NF-κB signaling adaptation"

• View our new structure of the zebrafish STING CTT–TRAF6 complex: PDB 6MYD

2019 - 04 - 15 Kailey Slavik from HMS Virology starts a graduate rotation in the lab.

2019 - 03 - 01 James wins a graduate award from the Albert J. Ryan Foundation.

2019 - 02 - 20 Our paper with the Mekalanos Lab on bacterial cGAS/DncV-like NTases (CD-NTases) is published today in Nature.

• Congratulations to Aaron, co-authors, and our collaborators in the Lee Lab.

• Read the manuscript: "Bacterial cGAS-like enzymes synthesize diverse nucleotide signals"

• View our new structures of CD-NTase enzymes and a host immunity receptor in complex with a cyclic trinucleotide: PDB 6E0K, 6E0L, 6E0M, 6E0N, 6E0O, 6M7K

• Read Chris Waters' preview of our work in Cell Host & Microbe: "Pyrimidines and Cyclic Trinucleotides Join the Second Messenger Symphony"

2019 - 02 - 19 Hsiao-Yun Chen starts in the lab as a postdoctoral fellow.

2019 - 02 - 06 Our paper on how poxviruses defeat cGAS-STING immunity is published today in Nature.

• Congratulations to James and our collaborators in the Kupper Lab.

• Read the manuscript: "Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling"

• View our new structures of the poxin nuclease stolen from an insect host-pathogen arms race: PDB 6EA6, 6EA8, 6EA9

• Read highlights of our work:

"Virology: Poxins Soothe the STING" (Andrea Ablasser, in Current Biology)

"A Poxin on Both of Your Houses" (Ming Hammond, in Biochemistry)

"A Pox on Your Messenger" (UniProt Featured Article)

2018 - 11 - 07 Aaron wins an outstanding postdoc award from HMS.

2018 - 08 - 06 Kacie McCarty starts in the lab as a research technician.

2018 - 08 - 01 Our work on cGAS is supported by the Concern Foundation.

2018 - 07 - 12 Our lab's first paper is published today in Cell.

• Congratulations to Wen, Aaron, co-authors, and our collaborators in the Mekalanos Lab, Lee Lab, Gray Lab, and Fischer Lab.

• Read the manuscript: "Structure of the human cGAS–DNA complex reveals enhanced control of immune surveillance"

• View our new structures of the human cGAS–DNA complex: PDB 6CT9, 6CTA

• Read Andrea Ablasser's preview of our work in Immunity: "Human cGAS Has a Slightly Different Taste for DNA"

• Read the press releases: Harvard Medical School "Guardian of the Cell" and Parker Institute for Cancer Immunotherapy "Key Cancer Detection Protein"

2018 - 03 - 31 Brianna Lowey joins the lab for her graduate dissertation work.

2018 - 02 - 26 Our work on STING signaling is supported by the V Foundation.

2018 - 01 - 03 Brianna Lowey from HMS Virology starts a graduate rotation in the lab.

2017 - 10 - 17 Our work on cGAS-STING signaling is supported by the Parker Institute for Cancer Immunotherapy.

2017 - 09 - 18 Benjamin Morehouse starts in the lab as a postdoctoral fellow.

2017 - 09 - 15 Our work on STING activation in cancer immunotherapy is supported by the Novartis Drug Discovery and Translational Research Program.

2017 - 08 - 31 Our collaborations with the Doudna Lab and Meyer Lab at UC-Berkeley are published today in Cell.

• Congratulations to Katjuša, Lucas and Kevin.

C. elegans DPY-21 H4K20 Demethylase: "Dynamic control of X-chromosome conformation and repression by a histone H4K20 demethylase"

• Nme Cas9–AcrIIC1 Phage Inhibition: "A broad-spectrum inhibitor of CRISPR-Cas9"

2017 - 08 - 01 Wen Zhou starts in the lab as a postdoctoral fellow.

2017 - 07 - 13 Carina wins a postdoctoral fellowship from the Cancer Research Institute.

2017 - 06 - 25 Our work on STING and cancer immunotherapy is supported by the Cancer Research Institute CLIP Program.

2017 - 06 - 23 Apurva Govande joins the lab for her graduate dissertation work.

2017 - 04 - 25 Aaron wins a postdoctoral fellowship from the Jane Coffin Childs Memorial Fund.

2017 - 04 - 10 Apurva Govande from HMS Virology starts a graduate rotation in the lab.

2017 - 03 - 15 James Eaglesham joins the lab for his graduate dissertation work.

2017 - 01 - 09 James Eaglesham and Hembly Rivas from HMS Virology start their graduate rotations in the lab.

2017 - 01 - 05 Our work on STING signaling is supported by the Charles H. Hood Foundation Child Health Research Awards Program.

2016 - 12 - 13 Our work on RNA second messengers is supported by the Smith Family Awards Program for Excellence in Biomedical Research.

2016 - 12 - 05 Carina de Oliveira Mann starts in the lab as a postdoctoral fellow.

2016 - 10 - 03 Colin O'Leary from HMS Virology starts a graduate rotation in the lab.

2016 - 09 - 24 Aaron Whiteley starts in the Mekalanos lab and Kranzusch lab as a postdoctoral fellow.

2016 - 09 - 06 Eric Nieminen starts in the lab as a research technician.

2016 - 08 - 04 Our collaboration with the Lee Lab at Brandeis and Cate Lab at UC-Berkeley is published today in Nature.

• Congratulations to Amy.

• Read the manuscript: "eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation"

• Check out our new structures of the eIF3d cap-binding domain: PDB 5K4B, 5K4C, 5K4D

• Read the Cate Lab UC-Berkeley press release: "When targeting cancer genes, home in on the 1 percent"

2016 - 08 - 01 The Kranzusch Lab begins research at Dana-Farber Cancer Institute and Harvard Medical School.

© 2021, Kranzusch Lab