Recent Publications

Nucleotide signals coordinate activation and inhibition of bacterial immunity.
Yamaguchi S, Fernandez SG, Wassarman DR, Lüders M, Schwede F, Kranzusch PJ.
Nature. 2026; Advanced online publication. (Link).

Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity.
Wassarman DR, Pfaff P, Paulo JA, Gygi SP, Shokat KM, Kranzusch PJ.
Science. 2025; 389(6767), 1347–1352. (Link).

A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense.
Chang RB, Toyoda HC, Hobbs SJ, Richmond-Buccola D, Wein T, Burger N, Chouchani ET, Sorek R, Kranzusch PJ.
Molecular Cell. 2025; 85(16), 3151–3165. (Link).

Animal and bacterial viruses share conserved mechanisms of immune evasion.
Hobbs SJ, Nomburg J, Doudna JA, Kranzusch PJ.
Cell. 2024; 187(20), 5530–5539. (Link).