Recent Publications

Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity.
Hobbs SJ, Wein T, Lu A, Morehouse BR, Schnabel J, Leavitt A, Yirmiya E, Sorek R, Kranzusch PJ.
Nature. 2022; 605(7910), 522–526. (Link).

Bacterial gasdermins reveal an ancient mechanism of cell death.
Johnson AG*, Wein T*, Mayer ML, Duncan-Lowey B, Yirmiya E, Oppenheimer-Shaanan Y, Amitai G,
Sorek R#, Kranzusch PJ#.
Science. 2022; 375(6577), 221–225. (Link).

cGAS-like receptors sense RNA and control 3′2′-cGAMP signaling in Drosophila.
Slavik KM, Morehouse BR, Ragucci AE, Zhou W, Ai X, Chen Y, Li L, Wei Z, Bähre H, König M, Seifert R, Lee ASY, Cai H, Imler JL, Kranzusch PJ.
Nature. 2021; 597(7874), 109–113. (Link).

cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing.
Zhou W, Mohr L, Maciejowski J, Kranzusch PJ.
Molecular Cell. 2021; 81(4), 739–755. (Link).

Contact

Philip J. Kranzusch, Ph.D.
Associate Professor of Microbiology
Harvard Medical School
Dana-Farber Cancer Institute
philip_kranzusch [at] dfci.harvard.edu

© 2022, Kranzusch Lab