Recent Publications

cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing.
Zhou W, Mohr L, Maciejowski J, Kranzusch PJ.
Molecular Cell. 2021; 81(4), 739–755. (Link).

STING cyclic dinucleotide sensing originated in bacteria.
Morehouse BR, Govande AA, Millman A, Keszei AFA, Lowey B, Ofir G, Shao S, Sorek R, Kranzusch PJ.
Nature. 2020; 586(7829), 429–433. (Link).

CBASS immunity uses CARF-related effectors to sense 3′–5′- and 2′–5′-linked cyclic oligonucleotide signals and protect bacteria from phage infection.
Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee ASY, Kranzusch PJ.
Cell. 2020; 182(1), 38–49. (Link).

Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling.
Eaglesham JB, Pan Y, Kupper TS, Kranzusch PJ.
Nature. 2019; 566(7743), 259–263. (Link)

Contact

Philip J. Kranzusch, Ph.D.
Associate Professor of Microbiology
Harvard Medical School
Dana-Farber Cancer Institute
philip_kranzusch [at] dfci.harvard.edu

© 2021, Kranzusch Lab